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Tirzepatide has shown reductions of up to 2.4% , making it slightly more effective for diabetes management

For instance, in MAR709 Tyr 13 from GLP-1 is retained, and yet it does not activate GCGR

(Semaglutide)

Why it matters: A projected launch window is not the same as FDA approval

Eur J Physiother

In one phase 2 study: Pancreatitis was reported in about 0.4% of participants (1 out of 267) Gallbladder issues affected roughly 1.1%, with no cases in the placebo group Heart rhythm changes were reported more often in people taking retatrutide (about 6% compared to 3% with placebo) Liver enzyme increases were rare (around 1%), and overall liver health markers stayed stable over time