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The week-by-week timeline for retatrutide appears compressed, with researchers reporting faster onset of appetite suppression and earlier weight loss milestones

Retrieved 24 April 2022

3.2 Adipose tissue In humans, infusions of GIP(3-30)NH 2 during a hyperinsulinemic and hyperglycemic clamp reduce GIP-induced blood flow to subcutaneous adipose tissue and inhibit the increase in triacylglycerol clearance observed with GIP administration ( 2 increased free fatty acid (FFA) output and a higher FFA/glycerol-ratio, suggesting a reduction in in-situ re-esterification of FFA and lipolytic activity ( Nevertheless, GIP receptor antagonism is thought to exert beneficial metabolic effects due to the expression of GIP receptors on adipocytes (94), along with elevated circulating GIP levels observed in both individuals with obesity (95) and individuals given a high-fat-diet (96)

doi: 10.1161/HYPERTENSIONAHA.111.175315

It was noted as being the first FDA-approved type 2 diabetes medication to reduce major adverse cardiovascular events (MACE) in adults
