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Subsequent pursuit of additional incretins eventually led to the discovery of glucagon-like peptide 1 (GLP-1) in 1987 1416

At full doses, some studies found that these medications may influence aging at both a cellular and systemic level by improving metabolic efficiency, reducing inflammation and shielding the body from the biological stressors that accelerate age-related decline

J Diabetes Metab Disord Control

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These findings demonstrate that Gipr Syn/ mice are resistant to the weight-lowering effects of mGIPR-Ab, highlighting the crucial role of CNS GIPR for the body weight response to mGIPR-Ab