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46 Activation of signalling cascades downstream of TLRs results in increased production and release of tumour necrosis factor (TNF), IL-6 and other proinflammatory cytokines

Henderson SJ, Konkar A, Hornigold DC, Trevaskis JL, Jackson R, Fritsch Fredin M, et al

This may result in a major caloric deficit without the athlete fully realising it

The liver is always interacting with the gut-derived bacteria and microbial products, in a distinctive local immune environment, often hesitating in tolerance, since an intact intestinal epithelial barrier can protect the liver from an excess of gut bacteria and their metabolites [44]

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Due to its CNS action, the dual GLP- 1/GIP dual agonist exhibits these superior benefits [23]