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While liraglutide and semaglutide are the only GLP-1 analogs currently used in HS treatment, other GLP-1 agonists, such as, dulaglutide, exenatide, and albiglutide, may also hold promise for future research and therapeutic use in HS

Why Many Patients Interested in Future Therapies May Already Have Higher Health Risks It is important to recognise that many individuals researching emerging weight-management treatments may already have underlying risk factors such as: obesity or metabolic syndrome type 2 diabetes high blood pressure elevated cholesterol sleep apnoea These conditions increase cardiovascular risk independently of any treatment

364 The metabolic reprogramming is characterized by shifting glucose metabolism to aerobic glycolysis, including enhanced cytosolic lactate fermentation and PPP and decreased OXPHOS

By enhancing insulin secretion in response to meals, reducing glucagon release, and slowing gastric emptying, semaglutide helps lower blood sugar levels while promoting a sense of fullness

Geographic limitations and insurance prior-authorization delays can force unplanned pauses

Obesity Semaglutide is FDA-approved for weight management in those with a BMI 27 with comorbidities or BMI 30