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While ED and testosterone deficiency were uncommon in younger men, non-diabetic men with obesity on semaglutide showed a higher risk

[3] However, the precise contribution of each receptor pathway to gastrointestinal tolerability in a triple agonist has not been fully characterised in humans, and this attribution should be regarded as informed by class-effect data rather than confirmed mechanism

One study found that weekly treatment with semaglutide, a GLP-1 RA, reduced the risk of a combination of stroke, heart attack, and death from cardiovascular causes by 20% compared with placebo.

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