glp-1 drugs made from Medications: Everything You Need to Know America's Poison Centers - GLP-1

Tirzepatide expanded indications: Following FDA approvals in 20242025, tirzepatide (Zepbound/Mounjaro) has expanded labeling covering additional cardiovascular and metabolic indications

As the use of these agents continues to expand, perioperative clinicians are increasingly encountering patients receiving medications such as semaglutide, liraglutide, dulaglutide, and tirzepatide before surgical and procedural interventions

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Diabetes Obes Metab 21(3):640647

In addition, mechanical activation of chondrocytes, which occurs during injury, activates extracellular matrix degradative enzymes including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) [6]