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[DOI] [PubMed] [Google Scholar] 124.Koska J, Migrino RQ, Chan KC, Cooper-Cox K, Reaven PD

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Key Takeaways Injectable GLP-1s have significantly higher bioavailability than oral formulations, which can translate into stronger, more predictable clinical effects

[3] [4] These medications work by mimicking the action of glucagon-like peptide-1 (GLP-1) , a naturally occurring incretin hormone produced in the intestines in response to food intake

Romosozumab is a monoclonal antibody against osteostatin that not only inhibits the activity of osteostatin (sclerostin) and upregulates the Wnt signaling pathway but also blocks the RANKL pathway, antagonizes its negative regulation of bone metabolism, promotes bone formation, and inhibits bone resorption ( Recent preclinical and clinical studies have shown that gut hormones may have a profound effect on bone remodeling and, ultimately, bone structure and strength (Figure 4)