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This third lever is the most likely reason the body-composition split favors fat over muscle in the trial.[1] The shorthand for this is "single agonist" (one signal), "dual agonist" (two), and "triple agonist" (three)

This bidirectional relationship between psychotropic medications and metabolic dysfunction creates a self-reinforcing pathogenic cycle: psychotropic medications worsen insulin resistance, which contributes to reduced treatment efficacy, often leading to dose escalation or polypharmacy

Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial

[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Thomas DM, Crofford I, Scudder J, Oletti B, Deb A, Heymsfield SB

Although the name can be a bit misleading, Glucagon-Like Peptide-1 agonists (GLP-1s) are diabetes drugs that mimic the natural gut hormone GLP-1, which, unlike glucagon, decreases your blood sugar and reduces glucagon, especially after meals