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Quick Answer: Polyethylene glycol 3350 (MiraLAX) is generally considered the best first-line laxative for semaglutide-related constipation due to its gentle mechanism, predictable effects, and minimal systemic absorption

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SG is highly effective for achieving clinically significant weight loss, with an average total body weight loss of 23% in one year and 16% following five years postoperatively (9, 10)

Then the development of oral GLP-1 RAs for treating T2D, and more recently, approvals of GLP-1/GIP co-agonists for T2D (in 2022) and obesity (2023)

Future investigations should implement standardized exercise prescriptions, longer follow-up, and preregistered multicenter designs to ensure methodological consistency and improve translational relevance

Despite the declines, GLP-1 users reported a continued desire to consume processed foods, sodas, refined grains and beef