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The implications are significant: Repurposing an inexpensive, widely available drug Targeting the intersection of inflammasome activation, TP53 dysfunction, and neoplastic risk Potential relevance for disorders ranging from CAPS and histiocytosis to MDS and beyond We urgently need more translational work on this underappreciated molecule

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The difference between those two endpoints, 213 versus 178, could be the difference between still meeting clinical criteria for obesity and reaching a normal BMI range

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The hair loss appears to be driven more by the magnitude and speed of weight loss than by the specific medication
