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Huadong Medicine Co., Ltd., Innovent Biologics, and Tonghua Dongbao Pharmaceutical Co., Ltd., are deep in advanced clinical stages

Sacubitril/valsartan has demonstrated consistent benefits not only in HF with reduced ejection fraction (HFrEF) but also in selected patients with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), especially women and those with borderline left ventricular ejection fraction, as shown in the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) and Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction (PARAGON-HF) trials and supported by Indian ARNI PRESERVED study

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GLP-1 receptor agonists, originally developed for managing type 2 diabetes, have rapidly emerged as highly effective treatment options for obesity

GLP-1 agonists may: Optimize high-risk patients before surgery Improve metabolic control Potentially reduce surgical risk But durable long-term outcomes in severe obesity still rely heavily on: Surgical intervention Lifelong follow-up Nutritional monitoring Multidisciplinary care The future may not be medicine vs surgery. It may be the intelligent integration of both