glp-1 news oct 16 2025 Alarming rise in weight loss drug overdoses FDA takes aim at telehealth

Switching to a different GLP-1 medication, reducing the dose, or considering alternative drug classes may be appropriate if symptoms remain intolerable

In doing so, it addresses several of the abnormal and disease-causing factors associated with obesity

Liraglutide (Saxenda) Saxenda received FDA approval on December 23, 2014 as the first GLP 1 receptor agonist specifically indicated for chronic weight management

Protein - preserving muscle while you lose weight On a GLP-1 diet, reduced calorie intake can increase the risk of lean muscle loss if protein intake drops too low

Powell DR, Smith M, Greer J, Harris A, Zhao S, DaCosta C, et al

Another important player in feeding regulation is the GABA LH neurons that project to the paraventricular hypothalamic nucleus (PVH)