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We hypothesised that the metabolite GLP-1(936) (previously believed to be biologically inactive) exerts a direct inhibitory effect on glucagon secretion and that this mechanism becomes impaired in diabetes

After matching, the analysis included 546 GLP-1 receptor agonist users and 546 non-users with similar baseline characteristics

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Full order partial correlation analysis A full order partial correlation analysis 46 was carried out to understand the strength of relationship between clusters