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In the 70s, other appetite suppressants appeared on the scene, recommended for safe (but limited) usage

F., Schmidt, W

doi: 10.1016/j.deman.2023.100145

Phase 3 ACHIEVE trial completed March 2026

However, direct comparisons require caution because: Trial lengths differed Dosing protocols differed Patient populations differed Long-term orforglipron data is still developing A 5% to 10% reduction in body weight can still produce clinically meaningful improvements in blood pressure, insulin sensitivity, mobility, and metabolic health

Surveys reveal that 61% of Americans say they are currently trying to lose weight, and at least 4% are already taking prescribed medications for weight loss