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Recent data also suggest that some antiinflammatory effects of GLP-1RAs may be centrally mediated even with minimal penetration (218)

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Regular monitoring allows early detection of dosing shifts and prevents the hypothyroid symptoms that can complicate weight loss efforts

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Although the aforementioned studies indicate that central mechanisms modulate the ability of GLP-1R agonists to reduce alcohol intake, other mechanisms such as the gut microbiota may participate

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