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Description

While some studies report no increased risk of congenital malformations [2,3], other studies highlight specific organ systems, such as the cardiovascular, central nervous, and gastrointestinal systems, as particularly vulnerable to GLP-1RA exposure [4]

Clarifying these interactions may inform the clinical use and further development of GLP-1 receptor agonists as effective treatments for AUD

Seek emergency care immediately (call 911 or go to the nearest emergency department) for: Severe, sudden abdominal pain with inability to pass gas or stool (possible obstruction) Vomiting fecal-material or persistent bilious vomiting Signs of severe dehydration (dizziness, decreased urination, confusion) Your provider may need to perform a physical examination, review your medication regimen, and potentially order investigations such as abdominal imaging if complications are suspected

Modulation of gut microbiota Recent research suggests that GLP-1 receptor agonists significantly affect the composition of gut microbiota, revealing a new mechanism that contributes to metabolic advantages (Liang et al