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[DOI] [PubMed] [Google Scholar] 80.Imbernon M, Saponaro C, Helms HCC, Duquenne M, Fernandois D, Deligia E, et al

The mechanisms underlying rheumatoid arthritis are complex and multifactorial, involving adaptive immune responses that may not be adequately addressed by GLP-1 receptor modulation alone

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However, because intraamygdala injection cannot be a part of the response to systemic GLP1, we have to assume that adverse effects seen in response to systemically administered GLP1 receptor agonists are different to those elicited by activation of GLP1 receptors behind the BBB

However, retatrutide has higher discontinuation rates and an emerging safety signal (dysesthesia) not seen with the other medications

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