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With the anti-obesity pharmacotherapy landscape rapidly evolving, two investigational agents from Eli Lilly have recently demonstrated highly promising Phase 2 results: Retatrutide (LY3437943) and Eloralintide (LY3841136)

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They lost about 8% of their body weight in 24 weeks.1 Individuals who gained back some weight after surgery lost almost 9% of their body weight after six months of taking liraglutide or semaglutide.2 People who had surgery and started gaining weight again lost about 10-15% of their weight after six months of taking semaglutide or tirzepatide.3 In summary, obesity is a complex disease that requires a variety of tools to manage it long-term

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Semaglutide shows promise in reducing tobacco use disorder-related health encounters in patients with type 2 diabetes, but further clinical trials are needed to confirm its efficacy.