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N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

Lancet Diabetes Endocrinol 7(7):515527 Perkovic V, Heerspink HL, Chalmers J, Woodward M, Jun M, Li Q et al (2013) Intensive glucose control improves kidney outcomes in patients with type 2 diabetes

Recently, several genetic factors contribute to the predisposition of obesity, and several genes that regulate body weight and metabolism have been identified
This review highlights the activation of GLP-1R-induced suppression of feeding as well as the modulation of neuronal electrophysiological properties of several brain regions in medulla oblongata, pons, mesencephalon, diencephalon, and telencephalon

GLP-1 is contraindicated during breastfeeding, so postpartum use typically happens after weaning
