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It should not be used during pregnancy for weight management and is not recommended in patients with severe gastrointestinal disease

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Because these hormonal pathways can be tied to numerous bodily processes, researchers are now trying to study what else GLP-1 analogs could potentially treat

Pharmacodynamics Mean body weight was decreased by 1.4 and 5.0 kg with semaglutide 0.5 and 1.0 mg, respectively, compared with an increase of 1.1 kg with placebo in Japanese subjects [estimated treatment difference versus placebo 2.4 kg ( p 0.05) and 6.1 kg ( p 0.05)]