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The presence of GLP-1 receptors in brain regions central to reward processing (Lpez-Ojeda & Hurley, 2024), together with evidence that GLP-1 RAs can modulate activity within these circuits (Gabery et al., 2020), has led to the hypothesis that GLP-1 RAs may reduce vulnerability to multiple maladaptive reward-seeking behaviors by blunting neuroaffective responses to reward-related cues (Eren-Yazicioglu et al., 2021
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[DOI] [PubMed] [Google Scholar] 65.Scott RB, Kirk D, MacNaughton WK, Meddings JB
