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Pain or tenderness in the affected leg or arm, which may only occur when walking or standing

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GLP-1 receptor agonists are commonly associated with gastrointestinal adverse events, which may lead to dehydration in some people [112]

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A 2025 review published in PMC ( Alopecia and Semaglutide: Connecting the Dots for Patient Safety , Branyiczky et al., International Journal of Dermatology ) specifically highlights micronutrient depletion particularly iron, zinc, vitamin D, and biotin as a primary pathway, noting these are well-recognised triggers for telogen effluvium. Hormonal disruption
Stress triggers the release of cortisol, a hormone that can disrupt hair follicles, resulting in excessive shedding
