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In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals

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3 Results 3.1 Base case analysis Total discounted lifetime costs, life-years (LYs), quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) are presented in Table 4

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