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Furthermore, the administration of Exendin-4 to SOD1 G93A mutant mice via a subcutaneous osmotic pump provides a steady-state infusion, improves glucose tolerance, normalizes running wheel behavior, and attenuates neuronal cell death in the lumbar spinal cord [147]

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These findings emphasize the importance of both the cellular composition and the functional status of adipose tissue immune cells in determining systemic and hepatic outcomes