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Type 2 diabetes mellitus in adults:As monotherapy in cases of intolerance or contraindications to metformin.In combination with other hypoglycemic agents (metformin, sulfonylurea derivatives, insulin, etc.) when adequate glycemic control cannot be achieved.

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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Sanders ME, et al

A triple agonist of GCGR, GLP-1R, and GIPR