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Abbreviations ADPKD: Autosomal dominant polycystic kidney disease PKD: Polycystic kidney disease FDA: Food and drugs administration USA: United States of America V2R: Vasopressin receptor-2 LVH: Left ventricular hypertrophy MRI: Magnetic resonance imagining LVMI: Left ventricular mass index SMO: Smoothened antagonist PCP: Planar cell polarity cAMP: Cyclic adenosine monophosphate CT: Computed tomography ciPTEC: Conditionally immortalized proximal tubular epithelial cells DNA: Deoxy-ribonucleic acid JAK: Janus kinase STAT: Signal transducer and activator of transcription MEK: Mitogen-activated protein kinase RAF: Rapidly accelerated fibrosarcoma ERK: Extracellular signal-regulated kinase MAPK: Mitogen-activated protein kinase CFTR: Cystic fibrosis transmembrane conductance receptor ESRD: End stage renal disease EGF: Epidermal growth factor EFGR: Epidermal growth factor SMPC: Summary of product characteristics AKT: Protein kinase B PI3K: Phosphatidylinositol-3-phosphate ER: Endoplasmic reticulum AAA: Abdominal aortic aneurysm mTOR: Mammalian target of rapamycin WPK: Wistar polycystic kidney PPAR: Peroxisome-proliferator activated-receptor gamma KEGG: Kyoto encyclopedia of gene and genomes GSEA: Gene set enrichment analysis PECAM-1: Platelet endothelial cell adhesion molecule-1 References Alpern MB, Dorfman RE, Gross BH, Gottlieb CA, Sandler MA

Importantly, semaglutide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)