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DOI: This research is funded by the U.S

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Verdict at a Glance Pemvidutide and survodutide are both GLP-1/glucagon dual agonists being developed for obesity and MASH, but survodutide is further ahead in clinical development with more advanced Phase 3 programs, higher-tier regulatory designations (Breakthrough Therapy vs Fast Track), and greater weight loss in Phase 2 (18.7% vs 15.6%)

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Cells were lysed in Trizol (Invitrogen) and total RNA was extracted