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And GLP-1 medications produce rapid, substantial weight reduction, with clinical trial participants losing an average of 13.6 kg on semaglutide and up to 25% body weight in the SURMOUNT 3 tirzepatide trial

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Comparative studies in GLP-1R knockout and wild-type mice have shown that GLP-1-dependent signaling alters gut microbial composition, with increased abundance of Gammaproteobacteria and Firmicutes, and reduced levels of Actinobacteria and Bacteroidetes

GLP-1 Medications and IBS Symptom Overlap Common side effects of GLP-1 therapynausea, constipation, diarrhea, and abdominal discomfortcan mimic or worsen existing IBS symptoms, making it difficult to distinguish between medication effects and disease activity