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3,4 Indirect Effects of GLP-1RAs The evidence points to the indirect effects of weight loss and systemic metabolic improvement as being the cornerstones of GLP-1RA efficacy in HF

At 10 mg/mL, 5 mg equals 50 units

Additionally, GLP-1RAs may activate receptors in cardiac myocytes, leading to the secretion of atrial natriuretic peptide (ANP), which promotes natriuresis, vasodilation, and inhibition of the RAAS [90]

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Adherence is low Despite growing demand, adherence remains a costly challenge

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