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GLP-1RAs also exhibit inhibitory effects on Angiotensin II (Ang-II) and its proinflammatory actions in the glomerulus, providing an additional layer of protection against kidney damage [100]
The study reported changes in model-system outcomes under experimental conditions, but these findings remain limited to preclinical research and should not be interpreted as clinical conclusions
GLP-1RAs stimulate insulin secretion in a glucose-dependent manner, therefore, reduce the risk of hypoglycemia
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In obese individuals, GLP-1 infusion acutely decreased creatinine clearance (29)
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