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The outgoing medication decays while the incoming medication accumulates
Change from a dose of basal insulin to two doses of premixed insulins The total dose will usually be maintained

They work through completely different mechanisms in completely different systems

10.1016/j.cell.2015.02.023 [DOI] [PMC free article] [PubMed] [Google Scholar] Gaykema, R

The SURMOUNT-1 trial showed that tirzepatide produced even greater weight loss in many patients
Future research should focus on identifying heterogeneous treatment effects specifically, determining which patients are most likely to benefit and who may be at greater risk for safety concerns, Guo said.