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The first study reported attenuation of nicotineinduced locomotor hyperactivity and sensitization, nicotineconditioned place preference and nicotineinduced accumbal dopamine release (measured by microdialysis) after acute systemic exenatide administration (Egecioglu, Engel, & Jerlhag, 2013b)

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may escalate to 1 mg or 2 mg weekly based on glycaemic response For oral semaglutide (Rybelsus) used in type 2 diabetes: Starting dose: 3 mg once daily for 30 days Increase to 7 mg once daily

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Both medication options have their own FDA approvals, meaning Mounjaro should not be used for weight loss, and Zepbound should not be prescribed for diabetes

GLP-1RA treatment also mitigates experimental diabetic cardiomyopathy by the indirect mechanisms of augmenting glucose oxidation in cardiomyocytes [84]