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Digestive Side Effects Nausea, vomiting, and diarrhea are common with tirzepatide, especially during dose changes

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Dehydration and acute kidney injury (AKI): Nausea, vomiting, and reduced fluid intake during dose escalation may lead to dehydration

Some people find the drugs unbearable

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If its almost time for your next scheduled dose (less than three days), then skip the missed dose and simply continue to follow your regular dosing schedule