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Some data suggests that injecting before 8am may produce slightly lower post-prandial glucose levels compared to evening injections, with one analysis showing a 15% improvement in post-meal blood sugar management

This is evident from studies where exenatide blunted the fMRI signal in brain areas such as the amygdala, insula, hippocampus, and frontal cortex in obese individuals but not in lean individuals [16, 17]

[1] However, consistency in timing may help with adherence and potentially minimize side effects

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demonstrated an acute improvement in post meal glucose levels, despite no increases in insulin release