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The use of GLP-1RA is a new therapeutic strategy that addresses both metabolic and cognitive/neuropsychiatric aspects, which is fundamentally important for the treatment of comorbid diseases.

The authors explicitly suggest reframing switching as part of long-term optimization rather than discontinuation

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Structured de-escalation of GLP-1 receptor agonists may lead to sustained health benefits while reducing treatment burden, according to data shown at the Obesity Medicine Association’s annual conference.“What I found was actually surprising, where in addition to losing weight initially on the weekly regimen, people actually lost further weight on the every-other-week