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Key Mechanism: Fiber slows digestion Reaches the colon fermented by gut bacteria Produces compounds that trigger GLP-1 release Two-Phase Effect: Immediate GLP-1 release after eating Second boost (48 hours later) Second Meal Effect Helps: Reduce cravings between meals Improve next-meal appetite control Best Fibers for GLP-1 Fermentable Fibers (Most Effective) Beta-glucans: Oats Barley Rye Seaweed Mushrooms Other Soluble Fibers Apples Pears Legumes: Lentils Chickpeas Peas 2

This study suggests a molecular crosstalk between the E2F1/pRb and GLP1R signaling pathways that modulates insulin secretion and glucose homeostasis

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Gastric inhibitory polypeptide (GIP) and glucagonlike peptide1 (GLP1) are the two primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic cells

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