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Limitations of Current Knowledge Although studied for decades, our understanding of the cascade of events beginning at glucose stimulation and leading to insulin secretion remains to be fully understood

Microbiome 9 , 34 (2021)

Big food companies expect the demand for GLP-1 drugs only to grow as the injected medication becomes available in pill form, which happened with Wegovy last week

Whether this should be regarded as specific metabolic treatment, targeting only the metabolic alterations of the syndrome, is debatable, since the improvement in metabolic conditions, e.g., insulin resistance, would tenably have a positive impact also in gonadal function in women with PCOS

Caution is warranted in patients with severe renal impairment, a history of diabetic ketoacidosis, or concurrent use of other serotonergic agents

Injectable Wegovy is available at a reduced cash price of ~$349 per month for uninsured patients