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Early GLP-1 development efforts were hindered by rapid degradation by dipeptidyl peptidase-4, short duration of action, and gastrointestinal intolerance at supraphysiologic exposure levels

Ideal semaglutide candidates include patients with BMI 30 or BMI 27 with weight-related comorbidities who have struggled with traditional diet and exercise approaches

Clinical studies : A 2024 cohort study in JAMA Ophthalmology reported a higher observed rate of NAION in patients prescribed semaglutide compared with those on non-GLP-1 therapies, suggesting an increased risk but not proving causation

In addition to helping people with obesity lower blood sugar levels, lose weight, and prevent heart disease, Wegovy has also shown promise for lowering risk of kidney disease, combating substance abuse, treating dementia, pancreatitis, and more

At the same time, GLP-1 reduces the production of glucagon, another hormone that raises blood sugar levels

Step 4: Order from a Licensed Pharmacy Only use FDA-approved, U.S.-based pharmacies