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Greater tolerability Tolerability is another factor to consider, given the intended long-term use of GLP-1s

Chronic stress elevates cortisol, which promotes visceral fat storage, breaks down muscle tissue, increases appetite for high-calorie foods, and impairs insulin sensitivity

For diabetic patients this creates challenges, as individuals who really benefit from these therapies are having a tough time obtaining the treatment they need

[DOI] [PMC free article] [PubMed] [Google Scholar] [204].Davies M, Pieber TR, Hartoft-Nielsen ML, Hansen OKH, Jabbour S, Rosenstock J, Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial, JAMA, 318 (2017) 14601470

Research demonstrates that GLP-1 receptor activation improves beta-cell function, reduces hepatic fat accumulation, and lowers inflammatory markers independent of substantial weight loss

Indeed, sarcopenia has been associated with impaired mobility, increased frailty, higher hospitalization rates and excess mortality [4]