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Imeglimin Imeglimin is a tetrahydrotriazine that was recently approved to treat type 2 diabetes in Japan (2021) and India (2022) and which has been shown to improve glucose-induced insulin secretion, especially first phase, in clinical trials [14]

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GLP-1 receptors are abundant in the pancreas, but are also found throughout the intestine, lung, kidney, heart, blood vessels, lymphocytes, and the peripheral and central nervous system (Figure 1)

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For instance, a study published in the New England Journal of Medicine reported that Liraglutide, a GLP-1 receptor agonist, led to substantial weight loss and improvements in glycaemic control in obese patients with type 2 diabetes

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2022;75(11 pt 2):2862-2866

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The impact of GLP-1 medications on the gut microbiota, which is partly mediated by gut IELs, may also affect the intestinal response to inflammation and its interaction with the host immune system, warranting further investigation

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However, this doesnt mean that its safe for everyone to take its still a prescription medication and should be treated as such, and with prescription medications come risks, such as adverse reactions, interactions with other medicines, and each individuals tolerance to the medicine

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