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The trial met both of its co-primary endpoints, which included weight loss and change in osteoarthritis pain
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However, patients with severe dyslipidemia, familial hypercholesterolemia, or very high LDL despite statins require specialist lipid managementGLP-1 therapy is complementary, not a replacement
36 In the STEP 8 trial in people with overweight/obesity without T2D, significantly greater improvements in the majority of cardiometabolic risk factors assessed were reported with semaglutide versus liraglutide
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