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Avoid repeated freeze-thaw cycles to maintain receptor binding affinity.Research Protocol Applications Glucose homeostasis and diabetes mechanism studies Weight management and appetite regulation research Cardiovascular protection and MACE prevention studies Neuroprotection and cognitive enhancement research Chronic kidney disease progression studies NAFLD/NASH mechanism investigations Anti-inflammatory pathway research Combination therapy optimization studies Clinical Translation PotentialGLP1-R research applications span from basic mechanism studies to translational research for multiple therapeutic areas

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However, the insulinotropic effect of incretins is diminished in type 2 diabetic patients, due in part to reduced expression of incretin receptors as a consequence of glucotoxicity