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These symptoms usually start to show up during the dose-escalation stages and get better as the treatment goes on

Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]

doi: 10.12659/MSM.883207

It is therefore implausible that short-term GLP-1 RA exposure alone would initiate de novo malignancy within a 1-year timeframe, particularly when considering even shorter exposure periods

Hypoglycemia: Particularly when used with other anti-diabetic medications

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