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By November, this number increased to 1,221, with 131 additional filings

In fact, there may even be patent applications in the USPTO today, almost 28 years after 1995, that were filed under the pre-GATT provisions and will expire 17 years from grant if they ever issue

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Alternative pharmacological options for managing type 2 diabetes and insulin resistance include: Metformin : Remains the first-line medication for type 2 diabetes, improving hepatic insulin sensitivity and reducing hepatic glucose production SGLT2 inhibitors : Promote glucose excretion through the kidneys and offer cardiovascular and renal protection Single-receptor GLP-1 agonists : Such as semaglutide, dulaglutide, or liraglutide Pioglitazone : A thiazolidinedione that directly improves insulin sensitivity, though weight gain and fluid retention limit its use For patients with non-diabetic hyperglycaemia (NDH), lifestyle modification remains the primary intervention