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Last reviewed: May 24, 2026 Last updated: May 24, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Neither the MHRA nor EMA recognise histamine intolerance as an adverse effect of tirzepatide in official product information or pharmacovigilance data

Recent studies have demonstrated that the GLP-1 agonist, liraglutide, exerts an antipsychotic effect in a mouse model of psychosis (Lietzau et al., 2020)

This could be due to enhancement of hepatic amino-acid catabolism with hepatic glucagon receptor activation

One interesting observation in this report is the onset of hyposalivation in which it was noted 4 weeks after starting semaglutide