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Phase 3 trial completion timeline Seven Phase 3 trials are expected to report results during this year

Retatrutide is a novel investigational agent that simultaneously activates GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

2025 Jan 9;20(Suppl 6):e088069

Its basic concepts include the following: it may reduce hunger by inhibiting the feeding center

Limited clinical data support the combination for weight loss, and both drugs independently reduce appetite, potentially amplifying side effects

Retatrutide has a half-life of approximately six days, meaning it takes roughly four to five half-lives, or about 24 to 30 days, to reach steady-state plasma concentrations at any given dose