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Data presented are for the efficacy estimand unless otherwise noted AHI apneahypopnea index (measured by polysomnography and reported in events per hour of sleep), CV cardiovascular, HF heart failure, HFpEF heart failure with preserved ejection fraction, hsCRP high-sensitivity C-reactive protein, KCCQ-CSS Kansas City Cardiomyopathy Questionnaire clinical summary score (range of 0100, with higher numbers indicating better quality of life), MASH metabolic dysfunctionassociated steatohepatitis, NASH nonalcoholic steatohepatitis, OSA obstructive sleep apnea, PAP positive airway pressure, SASHB sleep apnea-specific hypoxic burden, SBP systolic blood pressure, T2D type 2 diabetes Table 4

3 Biotech (2021) 11(4):179

44.Salehi S, Naghib SM, Garshasbi HR, Ghorbanzadeh S, Zhang W

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