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Summary Substantial clinical trial and real-world data has demonstrated the efficacy and long-term safety of GLP-1RAs in people with type 2 diabetes

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Regulatory agencies (FDA and European Medicines Agency) conducted exhaustive reviews and concluded theres no causal relationship

The inhibitory effect of GLP1 on glucagon secretion surpasses the glucagon-inducing effect of GIP, hence leading to effective glucose lowering

The lipid moiety is attached via a -glutamic acid spacer and two 8-amino-3,6-dioxaoctanoic acid (Ado) linkers , enabling reversible albumin binding in experimental systems