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Despite similar baseline characteristics, the tirzepatide groups showed significant reductions in HbA1c% with a pooled average of 68% of participants meeting the established criteria of 7.0% compared to 36% in the insulin Lispro group

These medications work by mimicking the action of the naturally occurring GLP-1 hormone, which is released from the intestine in response to food intake

The Benefits of GLP-1 Agonists for Weight Loss GLP-1 agonists have become a game-changer for weight loss for several reasons: Substantial Weight Reduction : Research indicates that patients using GLP-1 agonists can lose an average of 10-15% of their body weight over time, with some achieving more significant results

Although comparisons between tirzepatide and higher doses of dulaglutide (e.g., 4.5 mg) have yet to be done, these data argue against the concept that GIP coagonism can reduce the risk of GI adverse events